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Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

[DOI] [PubMed] [Google Scholar] 94.Roe CR, Millington DS, Maltby DA, Bohan TP, Kahler SG, Chalmers RA

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Using a novel iPSC-based 3-D model that recapitulates human BBB in vitro, a recent study showed that dysregulation of calcineurin/NFAT-signaling in pericytes induces apoE4-associated CAA pathology, whereas inhibition of calcineurin reduces apoE expression and vascular amyloid accumulation [67]
