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Description
The counteracted effects of lidocaine and bupivacaine [60,89] can suggest an extended effect even beyond the prime local anesthetic effect

During this process, ISR-associated kinases such as GCN2 and PERK phosphorylate eIF2 (Pontanari et al., 2025), thereby globally suppressing protein synthesis to reduce the mitochondrial folding load, while selectively enhancing ATF4 translation (Dang et al., 2023)

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BornsteinNMGuekhtAVesterJHeissWDGusevEHmbergVet al
