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Type II (moderate) : similar to type I, but more pronounced

These derivatives were evaluated in the kinetic resolution of rac -indanol to obtain a key intermediate in the synthesis of a drug used in the treatment of Parkinson's disease

Emran T, Chowdhury NI, Sarker M, Bepari AK, Hossain M, Rahman GMS, Reza HM (2021) L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction

Tumors with the highest rates of E-Cadherin loss included Merkel cell carcinoma (75.6% negative), anaplastic thyroid carcinoma (68.6% negative), lobular carcinoma of the breast (71.5% negative), and sarcomatoid (60.0% negative) and small cell neuroendocrine carcinoma (44.4% negative) of the urinary bladder