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In addition, several enzymes engaged in mitochondrial respiration are found to regulate ferroptotic cell death, such as SCO2 and fumarate hydrase (FH)[44, 116]

484 Since the severe toxicity of high-dose IL-2 and IFN- leads to the intolerance of patients to treatment and restrains the therapeutic efficacy in a large population, the combination of chemotherapies, targeted therapies or other immunotherapies with low-dose IL-2 or IFN- has been employed in some investigations to avoid the side effects brought by single high-dose cytokines therapy, which can meanwhile achieve better treatment response

Kuo CS, Chen CY, Huang HL, Tsai HY, Chou RH, Wei JH, et al

Neurodegenerative diseases Similar to muscle diseases, neurodegenerative conditions present altered mitochondrial homeostasis and NAD + metabolism, which have been thoroughly investigated as targets for NAD + modulation-based approaches 13,268,269