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We found that intracellular glutathione levels in T cells cocultured with Slc7a11 -knockdown (KD) dendritic cells significantly decreased under both normal conditions and oxidative stress induced by tert-butyl hydroperoxide (TBHP) (Supplemental Figure 10, CE)

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These findings echo those of similar rat studies by Khanna and Sharma, 35 Alaei et al, 36 and Kulkarni et al, 23 in which mice injected with morphine twice daily were found to be significantly less likely to develop tolerance and dependence to the drug if they were pre-treated with AA (400-1600 mg/kg)