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Microbiota-gut-brain signalling in Parkinson's disease: implications for non-motor symptoms

When co-cultured with macrophages, OCSCs increase the expression of M2-associated markers such as the mannose receptor (MR), interleukin-10 (IL-10), and arginase-1 (Arg-1), while simultaneously reducing the expression of M1 markers like tumor necrosis factor- (TNF-), inducible nitric oxide synthase (iNOS), and CD86

These pathomechanisms have motivated interest in antioxidant metabolites from botanical drugs and nutrients as complementary strategies

The process by which Astragalus membranaceus-Dioscorea opposita regulates the cell cycle and pathways to inhibit tumor cell proliferation is as follows: In CRC cells, the expression of cyclin D1 and CDK4 is inhibited by AS-IV, causing cell cycle arrest at the G0/G1 phase