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These diseases include chronic obstructive pulmonary disease (COPD), bronchial asthma, acute lung injury (ALI), chronic granulomatous disease (CGD), nonalcoholic fatty liver disease (NAFLD), hepatic ischemiareperfusion (IR) injury, kidney fibrosis, acute kidney injury (AKI), cardiovascular disorders, and cancer (Figure 2

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[PubMed] [Google Scholar] 142.Furlow WL, Swenson HE, Jr., Lee RE
However, the cause of this decrease is yet to be determined