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To date, three patterns of p-i-related hypersensitivity reactions have been proposed: the altered peptide model of p-i HLA, the allo-immune model of p-i HLA, and the p-i TCR model ( The altered peptide model of p-i HLA and the allo-immune model of p-i HLA were both developed because some ADRs generated by small molecule drugs are limited exclusively to the HLA allele (36)

Results Effect of AST on short-term memory in scopolamine-induced Alzheimers model in mice: Figure 1 shows that the scopolamine-induced AD group showed a significant decrease in SAP compared to the control mice

Type IIb fibers are the classic fast twitch fibers

Similarly, BHB has been shown to reverse the loss of dopaminergic neurons and glial activation and inhibit microglial pyroptosis by negatively regulating STAT3-mediated NLRP3, resulting in the downregulation of pro-inflammatory cytokines [85]