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[8] NADPH is needed for reductive biosynthesis , such as the synthesis of fatty acids, cholesterol, steroid hormones and two non-essential amino acids, proline and tyrosine, from glutamate and phenylalanine, respectively, as well as for the reduction of oxidized glutathione

Mutation of putative phosphorylation sites or truncation of the C terminal tail of OR have been extensively used to delineate the role of phosphorylation in desensitization

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