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Taken together, while direct clinical evidence in women with LPD is lacking, converging findings from menstrual cycle observations, animal models, and interventional studies suggest that progesteronekisspeptin signaling may contribute to GnRH/LH dysregulation and impaired follicular development, warranting further investigation (Fig
10.1007/s00415-020-09723-5 296 LubomskiM.XuX.HolmesA
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