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Neurosteroids required to induce changes in neuronal activity are present and act at extremely low (nanomolar) concentrations, in contrast to the high concentrations of gonadal and adrenal steroids produced for distribution through the circulation and action at distant sites throughout the body

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However, posthoc analysis of all of the fibrate trials show significant benefits in terms of reducing CVD events, when looking at the subgroup of patients with elevated triglycerides and low HDL-C and features of the metabolic syndrome or diabetes (670,671)