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Assuming a 1:1:1 group allocation ratio, a sample size of 29 teeth per group was required to achieve 80% power to detect between-group differences

It has been reported that the upregulation of TNF and IL-13 in intestinal tissues of IBD can promote both leak and pore permeability pathways, as feedforward and positive feedback controls of cytokine-induced intestinal barrier loss and vice versa as a vicious cycle

10.1002/bip.20543 [DOI] [PubMed] [Google Scholar] Schneider T, Kruse T, Wimmer R, Wiedemann I, Sass V, Pag U, et al