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KORs are highly expressed in the prefrontal cortex, nucleus accumbens, amygdala, and hippocampus, where they help regulate dopamine levels, modulate glutamate transmission, and maintain GABAergic inhibition [57]

We and others reported that the loss of OL in AD brain can be recapitulated in distinct transgenic mouse models carrying single ( APP (9)), double ( APP , PSEN1 (10)) and triple ( APP , PSEN1 , MAPT (1113)) genetic mutations associated with the amyloid cascade hypothesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Tkalcevic V.I., Cuzic S., Brajsa K., Mildner B., Bokulic A., Situm K., Perovic D., Glojnaric I., Parnham M.J

Technical Specifications: Components: (each 99% purity)