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The plausible main reason for -cell protective effects of GSH differing from other antioxidant effects is that GSH has multiple functions, such as maintaining levels of reduced glutaredoxin and glutathione peroxidase 35 and maintaining exogenous antioxidants such as vitamins C and E in their reduced (active) forms 36,37,38
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These transformations, instigated by the interplay between modified lipoproteins and endothelial cells, compromise intercellular junction integrity and increase endothelial permeability [38]
