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Wellness and therapeutic metabolites found in food and botanicals when taken in their natural matrix are generally safe even for chronic consumption, with extremely low toxicity, presenting ease in uptake or breakdown by the body, having low retention, and presenting low potential for physiological dependency [583]

Proliferation of DU145 prostate cancer cells is inhibited by suppressing insulin-like growth factor binding protein-2

The expression and function of OATPs are influenced by genetic polymorphisms, age, gender, and dietary factors, contributing to inter-individual variability in drug absorption, distribution, efficacy, and toxicity

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