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Resistance to mTORC1 inhibitors, such as temsirolimus involves an upregulation of glutamine metabolism, PTEN expression, alteration of the p53 response to nucleolar stress, a negative feedback activation of the PI3K/AKT signaling, increased rates of clonal and non-clonal chromosome aberrations, and changes in the copy number alterations pattern [412,413,414]

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GLP-1 RAs may inhibit retinal neurodegeneration and reduce proinflammatory processes, which could protect against diabetic retinopathy progression

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This route is initiated by cytotoxic agents and UV radiation

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