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10.1038/nm1577 25 OhtaS

The relative importance of the glutathione system compared to the more important thioredoxin system may be further amplified under acute oxidative challenge as thioredoxins or thioredoxin reductases may readily become limiting and/or oxidised and thus inactive [62], which would strongly limit the capacity of the thioredoxin pathway to act as a conduit of anti-oxidative electron flux

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Identification of an -Keto Ester Reductase for the Efficient Synthesis of an (R)--Lipoic Acid Precursor
