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The naturally occurring peptide GHK-Cu (GHK from glycyl-L-histidyl-L-lysine bound to a copper ion), which affects 31.2% of the human genes by either activating or deactivating them (based on a criterion of a reduction or increment in gene activity of more than 50%), meaning that it works by inducing epigenetic alterations in the cells

(20) Naturally, any errors in the reference p K a will introduce a constant error to the absolute p K a values

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This is not strictly necessary for a 28-day window under refrigeration, but it does not hurt