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Sox9 Deletion Causes Severe Intervertebral Disc Degeneration Characterized by Apoptosis, Matrix Remodeling, and Compartment-specific Transcriptomic Changes

The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs

Further subgroup analyses showed that patients who had undergone radiotherapy or concurrent chemoradiotherapy also exhibited lower DRS values and worse survival outcomes, implying that such pretreated patients may be particularly responsive to sermorelin [1] Finally, univariate and multivariate Cox regression analyses were performed to determine whether DRS was an independent prognostic factor

Identity is confirmed using LC-MS analysis to ensure molecular consistency with the intended sequence