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An ATF4-CHOP cascade is involved in the induction of ChaC1 under ER stress conditions, which results in the accelerated degradation of intracellular glutathione and may be responsible for cell death
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Furthermore, curcumin treatment led to the reduction in ROS and lipid peroxidation in cerebellum as well as improvement of reduced glutathione and glutathione-S-transferase in cerebrum which showed the neuroprotective behavior of curcumin on Al-induced neurodegenerative and behavioral disorders in rats [105]
