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Insulin resistance and aging: a cause or a protective response

In total, 8054 DEMs were detected in all leaf samples and were mainly classified into benzene and substituted derivatives (289), carboxylic acids and derivatives (633), fatty acyls (181), flavonoids (224), glycerophospholipids (322), organooxygen compounds (660), polyketides (261), prenol lipids (806), steroids and steroid derivatives (264), and others (3414) ( Figure 6A

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Klimek-Szczykutowicz M., Gawe-Bben K., Rutka A., Blicharska E., Tatarczak-Michalewska M., Kulik-Siarek K., Kukula-Koch W., Malinowska M.A., Szopa A

Nrf2 also regulates mitochondria-related genes, including the upregulation of the multifunctional DNA-binding protein mitochondrial transcription factor A (TFAM), which has a major impact on the expression of the mitochondrial genome, in addition to the transcriptional activation of essential function-related genes (such as NADH and NADHP formation-related enzymes, NOX) (Yang et al