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Description
In addition to its effects on neurotransmitters, the sleep peptide influences hormonal activity by lowering ACTH levels, which reduces stress-related cortisol production, and by enhancing growth hormone (GH) secretion, essential for restorative sleep

This approach minimizes injection frequency while maintaining therapeutic benefit

KOR activation induces presynaptic LTD via p38 (not PKA or MAPK) and calcium signaling in BNST at BLA, but not PFC inputs

[DOI] [PubMed] [Google Scholar] 146.Tessari P., Cecchet D., Cosma A., Vettore M., Coracina A., Millioni R., Iori E., Puricelli L., Avogaro A., Vedovato M
