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Description
During acute inflammation, pro-inflammatory M1-like macrophages accumulate in the liver, characterized by elevated expression of the NAD +degrading enzyme CD38 and increased CD38-dependent NADase activity, leading to reduced tissue NAD + levels (Stahl et al
Even unprocessed red meat at this frequency causes iron overload (inhibiting TPH1 activity) and elevates fecal pro-inflammatory Enterobacteriaceae abundance (308, 309)
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These symptoms are usually temporary
