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Of these, PEM and sleep disturbances are the hallmark symptoms of ME/CFS
PGE 2 contributes to pain hypersensitivity and hyperalgesia by lowering pain thresholds and by enhancing nociceptor sensory fiber excitability by activating EP1-EP4 receptors on nociceptors [91,112]
Other strategies are the adding of an additional stage to the STP
Li Hao F, Fang Han X, Li Wang X, Ru Zhao Z, Hong Guo A, Jian Lu X, Fei Zhao X (2019) The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells
