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In support with this, several studies highlighted that cells experiencing hypoxia or mitochondrial dysfunction have decreased glutamine oxidation and rely on carbon sources, other than glucose and glutamine, to supply metabolic intermediates under hypoxic conditions 46,47,48

So GSH, its S -conjugates, GSSG, -glutamyl di- or tripeptides, glutamine, l--methyl derivatives of -glutamyl amides, various lipid-derived mediators (e.g., leukotriene C4), geranylgeranyl, poly--glutamyl derivatives serve as substrates of GGT [33,34,35,36]

PMID: 39300112 Sci Signal Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

Glutathione is a tripeptide composed of three amino acids cysteine, glycine, and glutamic acid