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Spray administration: Administer a measured amount of the TB-500 nasal spray by gently pressing the applicator, releasing the spray into the subject's nostril

Because of the absence of a nucleus and mitochondria, the red cell is incapable of generating energy via the (oxidative) Krebs cycle and depends mainly on the anaerobic conversion of glucose by the Embden-Meyerhof pathway (EMP, or direct glycolytic pathway) and the oxidative hexose monophosphate pathway (HMP, or pentose phosphate shunt) (Figure 23-1)

This feature makes the release of antioxidants gradual, thus enhancing the regulated therapeutic impact of the treatment, and reducing side effects implications