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14: Immune Reconstitution and Chimerism O111 Pharmacological modulation of proteostasis as a strategy to boost thymic regeneration and T cell immunity Shirley Genah 1 , Marsha Pellegrino 1 , Manuela Giansanti 1 , Angelica Mancusi 1 , Alessio Taviani 1 , Marco Rosichini 1 , Antonella Cardinale 1 , Gabriele Volpe 1 , Francesca Nazio 2 , Emmanuel De Crespin De Billy 3 , Jarrod Dudakov 4 , Marcel van den Brink 5 , Franco Locatelli 1,3 , Enrico Velardi 1 1 Bambino Gesu Children Hospital, Rome, Italy, 2 TorVergata University, Rome, Italy, 3 Catholic University of the Sacred Heart, Rome, Italy, 4 Fred Hutch Cancer Center, Rome, Italy, 5 City of Hope, Rome, Italy Background : Thymic function is highly vulnerable to injury from cancer treatments, infections, and graft-versus-host disease (GvHD), leading to impaired T-cell development and reduced immune surveillance

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