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Interestingly, another histone demethylase, KDM5B, is highly expressed in melanoma persisters surviving BRAFi and MEKi treatments 35,40

Besides its glial role, GlyT1 can be found in both presynaptic and postsynaptic domains of glutamatergic neurons, where it exhibits spatial co-localization with NMDA receptors

In contrast, elderly patients, facing challenges such as immune senescence and comorbidities, would require lower doses of CAR T cells and strict monitoring for adverse effects to enhance safety (181, 182)