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438 Functional MRI studies have reported augmented blood oxygen level-dependent (BOLD) responses in limbic and striatal structures in response to heat pain in PDPN patients

Next, there is brachytherapy, which works by inserting the radioactive sources in or near the tumor site, enabling a high dose in a short period of time

J Immunol (2021) 207(1):5564

If you prefer precision or stronger effect, an injectable at 100500 mcg (perhaps every other day) may be appropriate always starting low
