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Residual lectins in inadequately purified extracts can bind to cell membranes, disrupting signaling pathways or eliciting immunelike responses (Samtiya et al
doi: 10.1021/acschembio.5b00245 6 DollSFreitasFPShahRAldrovandiMda SilvaMCIngoldIet al
Central administration of pharmacological ER stress inducers impairs leptin signaling, whereas treatments with chemical ER chaperons relieve hypothalamic ER stress and decrease body weights in ob/ob mice [184186]
