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Description
The intertwined dysregulation of copper and iron metabolism further exacerbates the disease by promoting apoptosis in lipid-rich foam cells and VSMCs, which are particularly vulnerable to metal-dependent cell death [195, 196]

FAQs Essentially yes

It is essentially a safety valve for the body

Indeed, we expect that not all targets will have geometries that will accommodate or otherwise be suitable for high-affinity binding to a helical segment
