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Activation of NF-kB/Rel proteins therefore requires degradation of IkB proteins via ubiquitin-mediated proteolysis to initiate nuclear translocation and DNA binding of active NF-kB/Rel complexes [84]

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Furthermore, F 2 -IsoPs have been shown to increase in different biofluids over the human lifespan (Reference Montine, Peskind and Quinn67) and to be higher in elderly versus younger subjects (Reference Sekhar, Patel and Guthikonda21)