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Monotherapy with cisplatin, ML385 or R16 induced only modest tumor inhibition (28.81% 12.31%, 23.93% 11.34% and 30.9% 14.88%, respectively), whereas combination therapy with cisplatin and either ML385 or R16 led to a striking reduction in tumor burden (80.29% 1.88% and 75.44% 7.4%, respectively) at 6 weeks after tumor engraftment (Fig

10.1038/ajg.2016.513 57

One of the most effective glutathione peroxidase mimics is ebselen, which is currently undergoing clinical trials for the treatment of rare inner ear conditions (Mnire's disease) and bipolar disorder
10.1038/sj.jid.5700613 [DOI] [PubMed] [Google Scholar] Hinz B., Celetta G., Tomasek J
