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[1] Because the cypionate ester markedly increases lipophilicity, the subcutaneous or intramuscular depot undergoes gradual enzymatic hydrolysis, releasing free estradiol that is chemically identical to endogenous estrogen and capable of binding to nuclear estrogen receptors in target tissues

above approximately pH 7.4 the Cu(II) chelate begins to release copper and the solution darkens

In an effort to give everyone a chance at a vaccine, theyve scheduled 2nd shots at 5 6 weeks after the first shot so that theres enough to go around