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In neuropathic pain, SAM dysregulation often manifests as sympathetic hyperactivity, which can directly drive pain via aberrant sympatheticsensory coupling, particularly after nerve injury

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This underscores the urgent need for novel therapies that target the underlying mechanisms of DN

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It's also studied for gut health, and is commonly used by athletes and in injury-recovery research, though it isn't an approved medication

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Biochem Pharmacol 37(5):881888 Ji L, Jiang P, Lu B, Sheng Y, Wang X, Wang Z (2013) Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism

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