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Description
MOTS-c appears to be one of the most potent natural activators of this cascade [1]

Vitamin B12 is a water-soluble vitamin which means any excess will be urinated out of your body (assuming you have normal kidney function), so the risk of overdose is basically non-existent

If left untreated, this can require surgical intervention or may even be fatal

A 2025 systematic review examined all published literature on the compound, identifying 544 total articles published between 1993 and 2024
