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[10] Ultimately, the best time to take vitamin B12 is whenever you can take it consistently

10.3390/biology11010147 188 RahmanM

Symptoms of deficiencyfatigue, weakness, paraesthesia, cognitive impairment, and mood disturbancestypically improve significantly with appropriate replacement therapy

Limitations of the Research Despite promising animal studies, key limitations remain: Human studies are sparse: Most research is conducted in rodents with few clinical trials