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Previously, IGF1R had been proven to be responsible for phosphorylating downstream cascade proteins in two main signaling pathways (i.e., the PI3K/AKT and Ras/MAPK pathways) [26] that promote multiple cell functions

Additional work showed that the NAC and vitamin E reduced levels of ROS and DNA damage in cancer cells, and essentially eliminated expression of the gene p53 a tumor suppressor gene that is typically activated by DNA damage

doi:10.1007/s10067-016-3168-2
10.1126/science.1523409 Science
