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Description
In MPTP animals, depletion of HexCer(t42:2), SHexCer(t43:2), and SM(d43:2) and an increase in SHexCer(d40:1) in the GPi and GPe correlated significantly with DAT scores in the Cd and Put (Supplementary Figs
Substance use disorder (especially alcoholism)
However, when this shield is overwhelmed due to an overproduction of free radicals or a failure of the antioxidant system, the redox balance shifts, resulting in a state of oxidative stress
And we can't forget the hormonal chaos
