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Nasca's animal studies suggest that acetyl-L-carnitine, a crucial mediator of fat metabolism and energy production throughout the body, plays a special role in the brain, where it works at least in part by preventing the excessive firing of excitatory nerve cells in brain regions called the hippocampus and frontal cortex

They documented reductions in free carnitine with intense training in agreement with the previous work of other researchers but provided the unique finding that carnitine supplementation alleviated all training induced deficits in total and free carnitine

doi: 10.1007/s10545-010-9190-7
