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your body can still regulate GH output to some degree (for example, if IGF-1 gets too high, feedback mechanisms can reduce further GH release)

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Epithalon and Geroprotective Outcomes A large, long-term study followed 266 elderly subjects (60+ years) over a 68 year period.(13,14) Participants were divided into groups receiving: Thymalin Epithalon A combination of Thymalin + Epithalon Control conditions Reported outcomes: Improved function of cardiovascular, endocrine, immune, and nervous systems Normalization of metabolic and hemostatic parameters Approximately 2 reduction in the incidence of common age-related diseases (e.g., acute respiratory illnesses, heart disease, and bone pathology) Decreased mortality: ~ 2-fold reduction with Thymalin ~ 1.8-fold reduction with Epithalon ~ 2.5-fold reduction with the combination These data suggest that Epithalon, alone or in combination with other peptide bioregulators, may exhibit geroprotective potential in elderly cohorts under specific experimental conditions

US Patent 5,164,367, 1992