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Wang XY, Liu WG, Hou AS, et al

B., Smith, C

The inflammation that caused the original blemish has gone, but the melanocytes it triggered are still active, continuing to deposit pigment long after they should have stood down

Physiologically, NRF2 is predominantly sequestered in the cytoplasm through its association with Keap1, which acts as an adaptor to oxidative or electrophilic stressors, such as elevated ROS, conformational changes in Keap1 disrupt its interaction with NRF2, leading to NRF2 stabilization and release (Yamamoto et al., 2018)
