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PubMed, Moore, Hyatt, et al
As a result of alternative promoter usage and alternative splicing the GCK gene gives rise to seven different mRNAs and seven different protein isoforms
and colleagues reported increased levels of Amyloid oligomers/protofibrils and A 1-42 in the brain tissue of postmortem TBI patients heterozygous for the APOE4 allele and concluded that soluble intermediary A tends to aggregate more rapidly after TBI in the presence of apoE4 [703, 704]
This has been previously described in a smaller cohort and attributed to a better capacity for re-methylation in women [36]
