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Castell L, Vance C, Abbott R, Marquez J, Eggleton P

(2011, American Journal of Pathology) reported that IGF-1 had plaque-stabilizing effects in a mouse atherosclerosis model useful as a half-life reference (~20-30 hours) and pathway marker

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Given that many tenocytes expressing the gene scleraxis (SCX) play critical roles during tendon healing (Best et al., 2021), the researchers conditionally deleted the IGF-1R in SCX-expressing tenocytes by using a tamoxifen-inducible Cre-recombinase system