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L.MingelsC.et al (2022)

Overall, existing evidence supports the pharmacological characteristics of ZSS, including multi-component synergy, multi-target regulation, and multi-pathway integration, and its direction of action is highly consistent with the current mainstream pathological hypothesis of depression

A study has shown that Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome, a member of the NLR family of intracellular sensors, also mediates sterile inflammation by regulating the release of the pro-inflammatory cytokine IL-1 which promotes peritoneal membrane damage and fibrosis (Hishida et al., 2019)

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