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By targeting energy regulation at the mitochondrial level, MOTS-c may improve endurance, protect against metabolic decline, and support muscle recovery making it appealing to both athletes and those interested in longevity

Indeed, combining TMAO with immune checkpoint blockade therapy, such as anti-PD1 and anti-TIM3 antibodies, further reduced tumor burden and improved survival compared to monotherapies alone

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Choline supplementation (5 g choline chloride/kg) in rats during pregnancy also protects against gestational inflammation mediated by LPS challenge, reducing the frequency of loss of fetuses, normalizing placenta weights, and attenuating LPS-induced NF-B activation and TNF-, IL-1, IL-6, and IL-17A levels in the placenta (47)