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Shi and coworkers, [299] found that Chlorogenic acid ameliorated the CCl 4 -induced fibrosis and liver inflammation in rats by downregulating the expression of TLR4/MyD88/NF-B pathway, which further coincided with the reduction of collagen I, -SMA, iNOS and COX-2 expression

Methotrexate, an antifolate drug used in cancer therapy, is a known inhibitor of DHFR, the enzyme that catalyzes the conversion of DHF into THF, which is required for the de novo synthesis of nucleotides for both DNA and RNA

Miro1dependent mitochondrial positioning drives the rescaling of presynaptic Ca2+ signals during homeostatic plasticity

Role of Surgery as Local Consolidative Therapy for NSCLC