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CYP2E1 expression decreases after a couple days in mouse and human hepatocyte cultures, so studies must be performed on freshly cultured cells

Studies that have used intra-putamen infusion of GDNF in an open-label format have observed improvements in motor UPDRS scores, as well as some indications of restoration of the nigrostriatal pathway, both pathologically and through imaging

Hart MP, Hobert O
