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In substantia nigra, the activation of microglia and the loss of reactive astrocytes in PD were confirmed by immunohistochemical detection of cr3 43 and ferritin (Mirza et al., 2000)
The timing, frequency, and extent of senescent cell removal remain open questions (for example, when is it best to clear them? What is the rebound or regenerative consequence?)
doi: 10.1016/S0955-0674(99)80013-1 41 BrissacT.MartnezE.KruckowK
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