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Most people who undergo chemotherapy and/or radiation report significant fatigue
(2025) 14:e040478

doi: 10.1016/j.jid.2022.03.029

Furthermore, heritability estimates range from 30 to 40% (Girgenti et al., 2021) with genome-wide studies implicating immune-linked loci such as ANKRD55 among others (Stein et al., 2016